Qiu Zhi-qiang
2007
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Journal
Fine and Specialty Chemicals
Abstract
Two pharmaceutical intermediates,namely 3-methyl-4-n-butyrylamino benzoic acid methyl ester and 3-methyl-4-n-butyrylamino-5-nitrobenzoic acid methyl ester were synthesized from 3-methyl-4-nitrobenzoic acid by series of reactions i.e. esterification, catalytic hydrogenation, condensation, nitration and refinement. The optimum process parameters were obtained based on several pilot plant experiments.