Xiao Zhu-ping
2012
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Influential Citations
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Quality indicators
Journal
Journal of Jishou University
Abstract
4-(4-Hydroxyphenethyl)benzene-1,2-diol is a new inhibitor against Helicobacter Pylori urease.The inhibition mechanism was herein investigated through enzyme kinetics methods,and the results revealed that 4-(4-hydroxyphenethyl)benzene-1,2-diol was competitive inhibitor of urease with a Ki value of 1.48 μmol/L.The chemical stabilitiy and the competitive mechanism of 4-(4-hydroxyphenethyl)-benzene-1,2-diol strongly suggested that it could be used as a lead compound for rational drug design to find active compound and as a potential urease inhibitor for treatment of gastritis and peptic ulcer.