D. Pettigrew, P. Roversi, S. Davies
May 15, 2009
Citations
1
Influential Citations
6
Citations
Journal
Acta Crystallographica Section D: Biological Crystallography
Abstract
The structures of two Dr adhesin (DraE) complexes with chloramphenicol derivatives, namely chloramphenicol succinate and bromamphenicol, have been solved. The structures reveal important functional groups for small-molecule binding and imply possible modifications to the molecule that would permit a more wide-ranging interaction without the toxic side effects associated with chloramphenicol.