Toshihiro Takahashi, T. Ido, R. Iwata
1991
Citations
0
Influential Citations
11
Citations
Journal
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes
Abstract
Abstract The effect of leaving groups on the introduction of [ 18 F]fluorine into fatty acids via nucleophilic fluorination has been systematically studied. It has been proved that tosylate and bromide are the most reactive among such leaving groups as chloride, bromide, iodide, mesylate, tosylate and triflate. This result has been applied to the synthesis of 17-[ 18 F]fluoro-3-methylheptadecanoic acid used in routine medical studies. Using methyl 17-bromo-3-methylheptadecanoate, the 18 F-labeled 3-methyl-branched fatty acid has been prepared in a radiochemical yield of 36–58% (based on 18 F − ) with radiochemical purities of > 97%.