Zhou Ping
2002
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Journal
Progress in Pharmaceutical Sciences
Abstract
To study on the Leuckart-wallach reaction. 1-[Bis-(4-fluorophenyl)methyl]piperazine was heated with various substituted benzaldehydes or ketones by the aid of formic acid. 1-[Bis-(4-fluorophenyl)methyl]piperazine was allowed to react with substituted benzaldehydes and formic acid . Under the same condition, 1-[bis-(4-fluorophenyl)methyl]piperazine was difficult to react with acetophone. [CONCLUSION]1-[Bis-(4-fluorophenyl)methyl]piperazine was formylated by formic acid resulting from the low activity of acetophone.