Yin Qiuxiang
2002
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Journal
Journal of Chemical Engineering of Chinese Universities
Abstract
cyclopropyl-7-chloro-6-(1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is the main impurity in the industrial manufacture of ciprofloxacin. The investigation of its physicochemical properties has important significance in the improvement of the crystallization and purification process of ciprofloxacin. The melting andde composition properties of 1-cyclopropy l-7-chloro-6- (1-piperazinyl)-4- oxo-1,4- dihydroquinoline -3-carboxylic acid hydrochloride and the relationships between the solubility and the ion strength, temperature and pH was studied systematically in this paper. The micro- and macro-dissolution constants and the solubility product have been estimated using the experimental solubility data by the proton equilibrium theory.