M. W. Nassar, Khalid A M Attia, Ragab A. M. Said
May 8, 2018
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Abstract
Lomefloxacin hydrochloride is chemically known as (RS)1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methylpiperazin-1-yl)4-oxoquinoline-3-carboxylic acid hydrochloride Figure 1. Lomefloxacin hydrochloride is a white powder soluble in water and methanol with 387.81 molecular weigth.1 It is a non-official drug which is known as a fluorinated 4-quinolone or fluoroquinolone antibacterial with a wider spectrum of activity than nalidixic acid and more favorable pharmacokinetics allowing its use in systemic infections. It has been used in the treatment of infections including bone and joint infections, gastro-enteritis (including travelers’ diarrhea and campylobacter enteritis, cholera, salmonella enteritis, and shigellosis), gonorrhea, infections in immunocompromised patients (neutropenia), Q fever, lower respiratory-tract infections, typhoid and paratyphoid fever.2 Literature survey reveals that many HPLC methods were reported for determination of lomefloxacin hydrochloride in pharmaceutical preparations and biological fluids.3–11 Also atomic absorption,11 spectrophotometric,12–19 spectrofluorimetric20–24 and electrochemical25–30 methods were reported for determination of lomefloxacin hydrochloride alone or in presence of other fluoroquinolone antibiotics. Reviewing the literature on the determination of lomefloxacin hydrochloride revealed the lack of any spectrophotometric methods for the determination of the intact drug in presence of its acid-induced degradation product. The aim of this work is to develop and validate simple, sensitive and selective spectrophotometric methods for the determination of lomefloxacin hydrochloride in the presence of its decarboxylated degradation product. Figure 1 Structural formula of lomefloxacin hydrochloride.