Chen Xue-xi
2012
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Guangzhou Chemical Industry
Abstract
3-amino-6-chloro pyridazine was an important intermediate of the fourth-generation cephalosporins: cefozopran.Maleic anhydride as the starting material,3-amino-6-chloro-pyridazine was synthesized through hydrazinolysis,halogenated reaction and microwave-assisted ammonolysis.The reaction conditions were optimized,the main factors affecting the reaction were discussed,the yield was good and the microwave-assisted reaction worked out well.1H NMR spectrum was used to identify the product from each step.