C. G. Staatz, A. Bloom, J. Lech
Jun 1, 1982
Citations
0
Influential Citations
49
Citations
Quality indicators
Journal
Pesticide Biochemistry and Physiology
Abstract
Abstract Permethrin ( cis-, trans- , and technical grade [tech.]) and deltamethrin, representatives of the non-cyano- and cyano-containing classes of synthetic pyrethroids, produced neurotoxic symptoms when administered to mice. ED 50 values for this effect were compared following intracerebroventricular (icv) or peripheral (iv) injection. Both permethrin and deltamethrin showed large increases in potency following icv administration, suggesting a mainly central site of action for both classes of pyrethroid. Pretreatment of mice with drugs affecting central noradrenergic, cholinergic, or serotonergic transmission was demonstrated to potentiate the toxic response to iv injections of tech.-permethrin, while some symptoms of toxicity could be partially alleviated by ip pretreatment with diazepam, aminooxyacetic acid, or cycloheximide.