L. A. Myshkina, T. S. Safonova
Aug 1, 1970
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Journal
Chemistry of Heterocyclic Compounds
Abstract
The reaction of 3-amino-2-mercapto-5,6-diphenylpyrazine I with phenyl halides in ethanol in the presence of an equimolecular amount of alkali has given 3-amino-2-phenacylthio-5,6-diphenylpyrazines (II–VII), while the reaction of I with chloroacetone or 1,3-dichloroacetone at 0°C has given 6-alkyl-6-hydroxy-5,6-dihydropyrazino[2,3-b]-[1,4]-thiazines (VIII and IX). The 6-aryl-2,3-diphenylpyrazino[2,3-b]-[1,4]-thiazines (X–XIV) have been synthesized by heating the 3-amino-2-phenacylthio-5,6-diphenylpyrazines (II–VI) with acetic anhydride.