Liu-zhou Gao
2004
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0
Influential Citations
1
Citations
Quality indicators
Journal
The Chinese Pharmaceutical Journal
Abstract
OBJECTIVE To study the pharmacokinetics of cefetamet pivoxil in 18 healthy volunteers after oral administration of 500 mg cefetamet pivoxil hydrochloride tablet.METHOD The concentrations of cefetamet in plasma and urine were measured by an improved HPLC method.RESULTS The results showed that the terminal phase plasma elimination half life ( t 1/2 ),peak plasma level ( c max ),area under plasma concentration time curve(AUC) were (2.52±0.47) h,(3.67±0.98) μg·mL -1 ,(21.1±5.19) μg·h·mL -1 ,respectively.CONCLUSION The plasma concentration time curve of cefetamet conformed to a two compartment open pharmacokinetic model.Cefetamet is mainly excreted through kidney in unchanged form.The cumulative urinary excretive rate of cefetamet was (36.0±8.62)% within 12 h after administration.