X. Wen, Zhang Dan
2007
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Quality indicators
Journal
Chinese Journal of Pharmaceutical Analysis
Abstract
Objective:The pharmacokinetics of azasetron hydrochloride in rabbits in vivo were investigated in this report.Method:HPLC was used to estimate the blood concentration of azasetron hydrochloride in rabbits after cau- dal vein(5mg·kg~(-1)weigh)and blood concentration-time curves as well as pharmacokineties parameters correla- ted were arrived at.Results:The concentration-time curve of azasetron hydrochloride in rabbit plasma could be fit- ted to two-compartment model.Conclusion:Azasetron hydrochloride was absorpted into blood and eliminated quickly.These findings could provide reference for clinical rational administration,moreover offer medical data in vi- vo for studying azasetron hydroehloride's correlated dosage forms.