Kafssi Hassan, W. Tao, Wan Ping-yu
2007
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Journal
Chemical Reagents
Abstract
3-[(1-ethoxycarbonyl-3-phenylpropyl) amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate tert-butyl ester is the intermediate of benazepril hydrochloride.The present work disclosed a novel process of using L-homphenylalanine alkyl ester,tert-butyl-3-bromo-2,3,4,5-tetrahydro-2-oxo-1H-benzazepine-1-acetate and 3-bromo-2,3,4,5-tetrahydro-2-oxo-1H-benzazepine as the starting materials for synthesis through two steps of alkylation.The effect of reaction conditions on the yield and the ratio of diastereomers were discussed.