Gao Wen-le
2014
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Journal
Chemical Research and Application
Abstract
Bendamustine hydrochloride,a derivant of nitrogen mustard,is a bioalkylating agengt,essentially used for the treatment of chronic lymphocytic leukemia and lymphomas. The process for its preparation generally suffers from the drawback of a high require of reaction condition. The synthetic process of bendamustine hydrochloride through seven main reactions,such as substitution,reduction,acylation,cyclization,reduction,alkylation,salification reaction etc was reported in this paper. A short synthesis route with mild reaction conditions,less steps,reducing the production cost and equipment requirements,a good prospect of industrialization,was provided.