Lai Hu-qin
2009
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Journal
Journal of Zhejiang University of Technology
Abstract
1-Hydroxycyclohexyl phenyl methanone was prepared from cyclohexane carboxylic acid by the reaction of acyl chloridation,Frield-Crafts reaction and α-hydroxylating with sodium hydroxide in the presence of carbon tetrachloride and PTC.The optimum reaction conditions were as follows: Frield-Crafts reaction temperature was 78 ℃,n(cyclohexyl carbonyl chloride)∶n(aluminum trichloride)=1∶1.1,n(cyclohexyl carbonyl chloride)∶n(benzene)=1∶4.The reflux time was 4 h.α-hydroxylating reaction time was 10 h.Under the optimal conditions,the overall yield of 1-Hydroxycyclohexyl phenyl methanone is 65% with the purity of 98.2%.The structure of 1-Hydroxycyclohexyl phenyl methanone was characterized by IR and 1H NMR.The advantages of the above synthetic process are easy operation,cheap raw materials.So it can be considered of a good prospect for the industrial application.