Ye Qing-guo
2008
Citations
0
Influential Citations
0
Citations
Journal
Chemical Intermediates
Abstract
The m-cresol is an important intermediate of synthesizing many fine chemical products.The diazotization and hydrolysis process was used to synthesize high-purity m-cresol using m-toluidine as the main material.The reaction conditions were optimized by orthogonal design and single factor design.It indicated that the optimal conditions as follows:n(sulphuric acid)∶n(m-toluidine)=2.8∶1,the concentration of sulphuric acid solution 35wt%,ordinal method in adding 27wt% NaNO2 solution,the adding time 40min.The yield of m-cresol could reach 85.2% under those optimized conditions and the purity was 99.5%.The configuration and contents were characterized by GS-MS.