C. Zong, Zeng Jing
2002
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0
Influential Citations
2
Citations
Journal
Chinese Journal of Pharmaceutical Analysis
Abstract
Objective: Study of the relation between dissolution of benorilate tablets and concentration in human plasma to establish dissolution method. Method: 1% Sodium laurylsulfate solution was used as the medium, paddles method was used with sampling after 45 minutes. UV spectrophotometry was adapted for the determination of dissolution of benorilate tablets. The concentration of benorilate in human plasma was estimated by using a HPLC method which has been developed to determine the hydrodytic products of benorilate paracetamol and salicylic acid with p - dimethy- laminobenzaldehyde as the internal standard. The relationship between dissolution and concentration of benorilate in human plasma was treated statistically. Results: A good relationship existed between the dissolution and pharmacokinetic parameters AUC, Cmax [ r = 0.968;0.985(n = 5),r0.01,3 =0.959]. Conclusion: The method established for benorilate tablets dissolution can control the sample quality effectively.