Kovalenko Lp, Sorokin Av, Popov Gr
May 1, 1990
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Quality indicators
Journal
Farmakologiia i toksikologiia
Abstract
: The preclinical study of safety of an antiarrhythmic drug bonnecor (GS-015) was carried out in the experiments on dogs. Administration of the drug in a dose of 5 mg/kg was found to exert no significant effect on functions of the vital organs. The dosage of 15 mg/kg can produce in dogs changes of the hematological and biochemical parameters and cause functional disorders of the cardiac muscle and death of the animals. The data obtained indicate that in dogs the drug possesses a little therapeutic range.