Luan Li-biao
2008
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
The Chinese Pharmaceutical Journal
Abstract
OBJECTIVE To study the intestinal absorption behavior of columbianetin acetate.METHODS Single pass perfusion model was used to study the absorption of columbianetin acetate at different drug concentrations and in various pH perfusion solutions respectively.The concentration of columbianetin acetate was determined by HPLC.RESULTS The absorption rate constants(Ka) and apparent permeability coefficients(Kapp) of columbianetin acetate were sequenced as follows colon ileum duodenum jejunum in four different regions of rat intestine.The Ka and Kapp of colon and ileum were significant different from those of duodenum and jejunum(P0.05).No difference(P0.05) in Ka and Kapp was observed in the concentration ranges of 61.93~165.14 mg·L-1 and in pH ranges of 3~5.CONCLUSION Columbianetin acetate can be absorbed in whole intestinal sections and colon is the best absorption region of whole rat intestines.The increase of columbianetin acetate concentration has no effect on absorption kinetics,the absorption of columbianetin acetate is a passive diffusion process.The absorption of the drug is not pH-dependent.