Li Aizhe
2015
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Journal
Journal of Guangdong Pharmaceutical University
Abstract
Objective To investigate the influences of light,temperature,humidity,oxygen remain and p H on the stability of cefotetan disodium,and the stability of the compatibility of complexes of cefotetan disodium with four other infusions. Methods The analysis method in USP was employed to determine the mass concentration of cefotetan disodium. The first method of appendix ⅨA of Ch P( edition 2010) was used to detect the colour of cefotetan disodium,and the first method A of appendix Ⅷ M of Ch P( edition 2010)was used to detect the water content of cefotetan disodium. Results Cefotetan disodium was sensitive to light,high temperature,high humidity,oxygen remain and p H,and can be used safely with four other regular infusions in clinic. Conclusion The conditions of packing,storage and clinical use of cefotetan disodium should be strictly controlled to ensure the safety and effectiveness of this drug.