L. D. Smirnov, L. G. Stolyarova, V. S. Zhuravlev
Jul 1, 1976
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Journal
Russian Chemical Bulletin
Abstract
1. The electrophilic substitution (iodination, aminomethylation, and azo-coupling) of 5-hydroxypicolinic acid Leads to the 6-substituted derivative, while the 4, 6-diiodo derivative can be formed in the case of iodination. 2. A COOH group in the 2 position of the hydroxypyridine ring lowers its ability to undergo electrophilic substitution or else it suppresses it completely, for example, in the case of nitration.