Sun Dong-dong
2011
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Journal
Fine Chemical Intermediates
Abstract
α,α-Diphenyl-4-piperidinemethanol,a key intermediate of Fexofenadine,was synthesized from 4-piperidinecarboxylic acid,thionyl chloride and ethanol by esterification,benzylation,Grignard reaction and de-benzylation.The overall yield was 80.85%.The product structure was confirmed by 1H NMR and IR.