Z. Quan
2006
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Journal
Tianjin Chemical Industry
Abstract
1-(2,3-dichlorophenyl)piperazine is a kind of pharmaceutical intermediate. The paper describes its synthesis from 2,6-dichloro-nitrobenzene and piperazine by alkylation, acidulation, reduction of nitro group, diazotization, substitution and hydrolysis. The total yield is 48.2%. The factors which influence alkylation, acidulation and reduction of nitro group are discussed. The structure of 1-(2,3-dichlorophenyl)piperazine is confirmed by IR and 1H-NMR.