Meng Ling
2006
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Journal
Fine and Specialty Chemicals
Abstract
1-(2-fluorophenyl)-1-(4-fluorophenyl) oxirane was synthesized by the reaction of 2,4'-difluorobenzophenone and trimethylsulphonium hydrogen sulphate in basic conditions.Through orthogonal experimental design,the optimum reaction conditions were determined: molar ratio of potassium hydroxide, methanol and 2,4'-difluorobenzophenone was 6∶1.25∶1,reaction temperature was 45℃.Calculated based on 2,4'-difluorobenzophenone,the yield and purity of 1-(2-fluorophenyl)-1-(4-fluorophenyl) oxirane was 91.23% and 97.45% respectively.