C. Pei-lin
2006
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Journal
Bulletin of Science and Technology
Abstract
In this paper,the synthesis process of 1,4-butanedisulphonate disodium salt was studied.The reaction time was shortened from 36 hours in the literature[1] to about only 3 hours in the addition of surfactant EDTA of the reaction system.The product yield is 99.39%.In order to analyze the concentration of 1,4-butanedisulphonate in the reaction system,an analytic method based on the high performance capillaries electrophoresis(HPCE) was established.The analytic conditions were as followings,column: uncoated CE capillaries with 50 μm×81 cm(AGILENT);Buffer: 20 mmol borate with pH=9.24;injecting voltage: 30 kV;injecting time: 5 s;and the wavelength of UV detector: 191.2 nm.Under above conditions,a linear relationship was observed between the concentration of 1,4-butanedisulphonate and absorbance.The precision,recovery and repeatability of the methods were evaluated.The results showed that the linear correlation coefficient for the method was 0.999,and recovery ratio was 96.5%.Coefficients of variation within and between days were 0.8% and 0.5%,respectively.The established analytic method is fast,accurate and repeatable,which has been successfully applied in the synthesis process of 1,4-butanedisulphonate disodium salt.