Yang Zhimin
2011
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Journal
China Medical Herald
Abstract
Objective: To optimize synthetic process of 1,4-dichlorophthalazine and to increase the yield.Methods: The target compound was synthesized from phthalic anhydride by condensation and chlorination reaction.Results: The synthetic process was improved,and the overall yield was increased to 85.0%.The structure of the synthetic compound was identified by HRMS and 1H-NMR.Conclusion: After the improvement synthesis process,the operation is simplified,the product quality is enhanced and the cost is decreased,the improvement synthesis process is feasible and practicable to the industrialization production.