Zeng-sun Jin
2015
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Journal
Journal of Xinjiang Normal University
Abstract
1-(6-Bromo-pyridin-3-yl)-ethanone was synthesized by using 2,5-dibromo-pyridine as thestarting material via two steps reactions of Magnesium halide exchange and nucleophilic substitution, 2-bromo-5-pyridyl magnesium chloride reacted with acetyl chloride smoothly in the presence of 2 mol% CuCl, 2 mol% LiCland 2 mol% AlCl3 as catalysts at 0oC to room temperature in THF. The total yield of two steps was up to 81%, Ob-viously the reagents used were readily available,corresponding procedures were very straightforward and reactionconditions were very mild.