Zhang De-hua
2009
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Journal
Chemistry World
Abstract
2,6-Dimethyl-3,4-dihydro-4-oxo-quinazoline is the key intermediate for the synthesis of anticancer drug Raltitrexed and its derivatives.2-Amino-5-methyl-benzoic acid was obtained via three steps with p-toluidine as starting material.Then,2,6-dimethyl-3,4-dihydro-4-oxo-quinazoline was prepared through cyclization.In the key step,acetamide was used to react with 2-amino-5-methyl-benzoic acid to yield 2,6-dimethyl-3,4-dihydro-4-oxo-quinazoline.