Dai Shi-gang
2011
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Journal
Hebei Chemical Industry
Abstract
The objective compound,2-carboxy-4-methoxyphenylacetic acid was prepared by three steps,including sulfonation,alkali fusion,and methylation reactions using 2-carboxyphenylacetic acid as raw material.Single-factor and orthogonal design method were applied to decide the better conditions of each factor in above three unit reactions,which offered a valuable synthetic process of 2-carboxy-4-methoxyphenylacetic acid with the average overall yield of 70.63% in three reactions.