Sun Chong-lu
2013
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Journal
The Chemical Engineer
Abstract
This thesis is mainly a detailed introduction of the process for preparing 2-chloro-6-fluorobenzenamine using 2-fluorobenzenamine as material,through acetylation,sulfonylation,ammonolysis,deacetylation,chlorine displacement,desulfonamide to obtain the intermediate of Lumiracoxib.This paper also studied the 2-fluoroacetanilide preparation process conditions through single-factor-experiments.The best condition was found: reaction time was 1 hour,the best material liquid ratio of 1∶1.25.The optimum amount of molar ratio was at 1∶4.5 in preparing 4-acetamido-3-fluorobenzene-1-sulfonyl chloride.The structure of target compound was confirmed by the analysis of H-NMR,IR.Under the optimal reaction conditions,the total yield of product was 29.8%.