Pan Wei
2012
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Journal
Chemistry & Bioengineering
Abstract
Taking 2-chloronicotinic acid as starting material and being sulfhydrylated by thiourea,2-thiobenzyl nicotinic acid is synthesized after the reaction with benzyl chloride.The optimum synthetic process was as follows:thiourea salt was prepared by 2-chloronicotinic acid and thiourea with molar ratio of 0.96∶1,and was hydrolyzed by 40% NaOH solution,then the benzyl chloride was added dropwise into the reaction system.The yield was 98.6%,higher than the values ever reported.