L. Xia
2014
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Journal
Hebei Journal of Industrial Science and Technology
Abstract
3-(hydroxymethyl)tetrahydrofuran is the key intermediate for preparing the third generation of synthetic insecticides dinotefuran and penciclovir,Lowe's,but for a long time the large usage amount of metal borohydride brings high cost,high security risk,waste and other shortcomings.In this paper,withγ-butyrolactone as raw material,through Aldol condensation and sodium borohydride reduction 3-(hydroxymethyl)tetrahydrofuran was prepared with a total yield of 51.9%.The intermediateα-hydroxymethyl-γ-butyrolactone has only one lactone carbonyl that needs to restore.The process uses lower cost materials and it is easily scaled up.