Zhang Liang
2008
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Journal
Journal of Wuhan Institute of Technology
Abstract
4-amino-1,2,4-triazole was synthesized from formic acid and hydrazine hydrate by condensation and cyclocondensation.Optimize the influence of the two-step reaction conditions.Under Optimal condensation conditions: n(formic acid):n(hydrazine hydrate) = 2.2∶1.0,condensation temperature 120 ℃,condensation time 6 h,yield of intermediate N,N-Diformylhydrazine is 92.3%;Under the optimal conditions of following cyclocondensation∶n(N,N-formylhydrazine)∶n(hydrazine hydrate)=1.0∶1.1,cyclocondensation temperature 160 ℃,cyclocondensation time 4 h,yield of 4-amino-1,2,4-triazole is 98.6%.Overall yield of 4-amino-1,2,4-triazole from above two step reactions is 91%.