Lin Yan-fang
2007
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Journal
Journal of Zhejiang University of Technology
Abstract
A useful intermediate,5-acetyl-4-methyl-2-(substituted anilino)thiazole,was prepared through three steps.First,the substituted aniline was refluxed with aqueous HCl and NH_4SCN to give substituted phenylthiourea with a yield of 45.7%~76.6%.Second,the 2,4-pentanedione was brominated in a mixture of CCl_4 and H_2O to form 3-bromo-2,4-pentanedione with a yield of 92.0%.Finally,a solution of substituted phenylthiourea and 3-bromo-2,4-pentanedione in acetone was refluxed and the titled compound thiazolone was obtained with a yield of 61.0%~69.1%.The structure of the obtained compound was identified by using IR,and ~1H-NMR.