Sun Zhi-zhong
2011
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Journal
Journal of Natural Science of Heilongjiang University
Abstract
In order to prepare the key quinazoline intermediate 6,7-bis(2-methoxyethoxy)quinazo-lin-4(3H)-one with better antitumor activity,the method of etherification,nitration,reduction and tcyclization was used for synthesizing 6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one by the four steps from ethyl 3,4-dihydroxybenzoate as the starting material.The total yield was more than 90% through the improved and optimized process.The improved process is a high yield,simple operation,environment friendly and suitable for scale production.