Zhong Wei-hui
2007
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Journal
Zhejiang Chemical Industry
Abstract
6,7-Dihydro-5H-cyclopentano[b]pyridine, a key intermediate of Cefpirome, was synthesized from cyclopentanone and propargylamine under autoclave prompted by copper(I) chloride. The optimum processing parameters such as catalysts, catalytic amounts, temperatures and solvents were investigated. The product yield is over 60% and the GC purity is over 99%.