Liu Hai-bin
2011
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Journal
Fine Chemical Intermediates
Abstract
6,7-Dimethoxy-4-(piperazin-1-yl)quinazoline(3)was prepared from the staring material 2-amino-4,5-dimethoxybenzoic acid through cyclization,chlorination and substitution in an overall yield of 61% under optimized conditions.The structure of compound 3 was characterized with 1H NMR and MS(APCI).The syntheses of the intermediates 1,2 and the final product 3 were explored.