Yuan Shi-tao
2008
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Journal
Journal of Qingdao University of Science and Technology
Abstract
Allantoin was synthesized using crystal glyoxylic acid and urea as raw materials by cyclization and condensation reactions.The effects of solvent kind,molar ratio of solvent,catalyst kind,molar ratio of reactant and reaction time on reaction results were examined.The results showed that the mixture of tetrahydrofuran and ethanol was a suitable solvent for the reaction and the yield of product was 85.4% with the purity of more than 98.9% under the following conditions:n(tetrahydrofuran)∶n(ethanol)=1∶1.5,n(glyoxylic acid)∶n(urea)= 1∶4,reaction time 4 h in the presence of mixture of sulfuric acid and phosphoric acid as catalyst.The structure of obtained product was characterized by FT-IR,1H NMR and 13C NMR.