Zhang Cong-fe
2013
Citations
0
Influential Citations
0
Citations
Journal
China Modern Medicine
Abstract
Objective To study the method of synthesis of guanine.Methods Guanine was synthesized by 2,4,5-3 amino-6-pyrimidine sulphate and sodium formate under the conditions of 3 atm and formic acid as the catalyst through acidification by hydrochloric acid,treated by ammonia water.The reaction yield was strongly dependent on the reaction factors such as raw materials matching,reaction time,and so on.Results The raw material radio(2,4,5-3 amino-6pyrimidine sulphate∶sodium formate) of 1∶1.5 and 8 h reaction time was the optimum technical condition.Conclusion It is the best method to synthesize guanine with simple technology,high percent recovery and short reaction time.