Pang Yan
2010
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Quality indicators
Journal
Fine Chemical Intermediates
Abstract
4-Chromanones are known to exhibit a wide range of biological activities.In order to study the structure-activity relationships of anti-platelet aggregative activity of 4-chromanone derivatives,Ten Mannich bases of 4-chromanone derivatives were designed,synthesized and characterized,among which compounds (5d~5g,5i~5j) were reported for the first time.The anti-platelet aggregative activity of the target compounds was tested using Born's method.Results revealed that all the target compounds showed good inhibitory activities against rabbit platelet aggregation induced by ADP in vitro.