Yang Chao
2008
Citations
0
Influential Citations
0
Citations
Journal
Journal of Northwest University
Abstract
Aim To synthesize N-((2-oxo-3-substituted-oxazolidin-5-yl)methyl)acetamide by a new way.Meth- ods The intermediate of glyeidylacetamide was prepared orderly by amination and cyclization of epichloeohydrin in the presence of protective agent of bezaldehyde.Reaction of N-substitutrd ethyl carbamate and glycidylaeetamide are carried out in the presence of catalyst to provide N-((2-oxo-3-substituted-oxazolidin-5-yl)methyl)acetamide.Re- suits Four N-((2-oxo-3-substituted-oxazolidin-5-yl)methyl)acetamides were synthesized.The total yield is 50%.The structure of the compounds was confirmed by IR,H NMR and elementary analysis.Conclusion The methods were mild and available for synthesis N-((2-oxo-3-substituted-oxazolidin-5-yl)methyl)acetamide.