Wang Zhi-xiang
2012
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Journal
Strait Pharmaceutical Journal
Abstract
A improved convenient method for synthesis of Dovitinib using 5-chloro-2-nitroaniline as the starting material,via substitution,reduction,cyclization with ethyl β-ethoxy-β-imino propanoate hydrochloride and then cycliztion with 2-amino-6-fluorobenzonitrile was carried out,with a total product yield of 44.1%.Structures of the intermediates and the target were confirmed by MS and 1H NMR.Compared to the literature method,the improved one has the advantages of low cost,convenient operation and broad prospects for commercial scale-up.