Xu Hua-jian
2009
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Journal
Fine Chemical Intermediates
Abstract
((R) -2 -[(tert -Butyloxycarbonyl)amino ] -3 -methylene -methylbutyrate, a precursor of β,γ - unsaturated α-amino acids, was synthesized from D-mannitol in eight steps with high stereoselectivity (82% e.e) and good overall yield (10.15%). During the process, the key and novel step is the Overman rearrangement.