Jiao Jun-ping
2007
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Journal
Journal of Northwest University
Abstract
Aim To prepare some 3-dimethylamino-1-3-heteroaryl-2-propen-1-ones.Methods By the reaction of acetyl heteroarylcycles such as acetyl pyridiness,acetyl thiophenes,or acetyl furans and the like,with N,N-dimethylformamide dimethylacetal in xylene solvent at 140℃ for 24 hours,3-dimethylamino-1-heteroaryl-2-propen-1-ones were prepared.Results Seven title compounds were prepared in yields of 86%~92%.The structure of the compounds were confirmed by IR,MS and 1HNMR.Conclusion The method of preparation is simple at mild condition in high yields.The compounds which were synthesized can be employed to replace the 4-pyridine moiety in Imatinib to obtain a series of new Imatinib′s analogues.