Zhang Wei-xing
2013
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Journal
Chemistry World
Abstract
The new synthesis process for 2-(4-aminophenyl) ethanol,a key intermediate of cardiovascular drugs,was studied using β-phenylethanol as raw material.Through four step reactions such as esterification,nitrification,hydrolysis,and reduction,the total yield of 2-(4-aminophenyl) ethanol reached 66.4%,and the HPLC purity was 99.77%.The product structure was identified with melting point and GC-MS.The new technology has great industrialized application value.