Liu Zong-lin
2013
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Journal
Applied Chemical Industry
Abstract
Using 6-bromo-5-hydroxy-1-methyl-2-phenyl methyl sulfide indole-3-carboxylic acid ethyl ester as raw material,the Mannich reaction of arbidol hydrochloride.The optimum synthesis process parameters were as follows∶ n(6-bromo-5-hydroxy-1-methyl-2-phenyl methyl sulfide indole-3-carboxylic acid ethyl ester)∶ n(dimethylamine) =1∶ 3,n(dimethylamine)∶ n(methanal)=2.2∶ 1,reaction time 2 h,reaction temperature 65 ℃.Under this condition,the yield was over 83%,the purity was more than 99.0%.