Tao Jing-chao
2007
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Journal
Journal of Xinyang Normal University
Abstract
Ranolazine is a novel anti-angina drug with brightly applicable prospect,but obstacles for the application of ranolazine include hard operation conditions,high piperazine consumption and low yield,etc.in the syntheses reported in literatures.Ranolazine was synthesized with 2,6-dimethyl aniline as starting precursor.Monohydrochloride piperazine was used instead of piperazine for the synthesis of N-(2,6-dimethylbenzyl)-1-piperazinylacetamine,resulting in decreased piperazine consumption.Reaction conditions such as reagents and temperature were optimized as well.The overall yield is up to 70.1%.The structure of the target product is confirmed by MS,IR,1H-NMR.The proposed synthetic method could be a choice for industrial production of ranolazine,due to its simple procedure,low production cost and low pollution.