Shuanglin Qin, L. Tang, G. Wang
Oct 1, 2014
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Journal
Advanced Materials Research
Abstract
Tert-butyl (4R)-4-(methoxymethylcarbamoyl)-2,2-dimethylthiazolidine-3-carboxylate, an key intermediate of the natural product Biotin which is a water-soluble vitamin, involved in an essential part of the metabolic cycle causing catalytic fixation of carbon dioxide in the biosynthesis of fatty acids, sugars, and α-amino acids, was synthesized from L-cystine in overall yield 54% through three steps. The study including acetonization, Boc protection, N-methoxy-N-methyl amidation.