Liu Guang-shen
2014
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Journal
Contemporary Chemical Industry
Abstract
Synthesis reaction principles of 2-chloro-3-(trifluoromethyl)pyridine were analyzed and summarized. It's pointed out that,N occupying on the pyridine ring and whether there is electron withdrawing group onαsite determine the feasibility of side-chain chlorination;in synthesis reaction,the difficulty of chlorinating is negatively correlated with the difficulty of fluorinating.