Anupama Chauhan, Ajay Kumar, A. Goel
2022
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Journal
Asian Journal of Organic & Medicinal Chemistry
Abstract
4-Formyl pyrazole is nitrogen containing heterocyclic aromatic molecule containing isoniazid moiety. The molecule is formed by fusion of two heterocyclic ring i.e. pyrazole and isoniazid. The current paper covers a vast range of methods for synthesis of 4-formyl pyrazole containing isoniazid moiety and its derivatives using variety of catalyst, solvent medium and microwave irridation with a goal of achieving a high yield and rapid separation of products. This work describes 4-formyl pyrazole and isoniazid antimicrobial activity as well as their structural-activity relationship. It also includes the mechanism of action of pyrazole and isoniazid and includes the list of current patents linked to various pharmacological activities in previous past years.